01
Meta-analysis of 8 clinical trials (316 participants) found substantial significant impact of CBD on anxiety disorders.
view on pubmed ↗← BACK TO VEDA
MENTAL WELLNESS
• MIXED
High Dose Cbd for Stress
RESEARCH
- CBD shows promise for anxiety in controlled studies, but evidence for stress specifically and optimal dosing remains unclear.
COMMUNITY
- Users report mixed results—some find it helpful for sleep and pain, but others experience concerning side effects like mania or disinhibition.
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SAFETYCBD may interact with medications metabolized by the liver; check with a doctor before use, especially if taking other drugs.
WHAT THE RESEARCH SAYS
ALL 15 ON PUBMED ↗02
Preclinical evidence strongly supports CBD for generalized anxiety, panic, social anxiety, OCD, and PTSD when given acutely; chronic dosing rarely studied.
view on pubmed ↗03
Double-blind trial tested CBD at 10–20 mg/kg/day for seizures; high-dose CBD was well-tolerated but efficacy data specific to stress/cortisol not reported.
view on pubmed ↗04
Retrospective case series found CBD improved anxiety and sleep complaints in psychiatric patients as adjunct to usual care.
view on pubmed ↗WHAT PEOPLE SAY
READ THREADS ON REDDIT ↗COMMUNITY SENTIMENT
60% positive
“I'm an experienced smoker. I took a break and used *broad* spectrum CBD (No THC) at the highest dose I could find to help me sleep in case I needed it. I took 200mg max, and it was enough to help me avoid the temporary insomnia when I stop smoking. I'd say it was enough to relax me. 450MG is an absolutely enormous dose.”
U/PABLOBABLO ↗“I have a CBD rub on stick 300 mg. Also has peppermint oil and menthol added. It works better than anything else I've tried for my osteoarthritis, with bone on bone in one knee. No side effects.”
U/[DELETED] ↗“CBD is capable of causing mania for me. Without fail every time I use it I find myself in some crazy debate or flipping out or acting disinhibited without realizing. Likely this is related to 5HT1a and GABA signaling. 5HT1a is the downstream target for many antidepressants. Many of those antidepressants produce mania in bipolar patients. It’s also worth noting that THC gives me more self control. But I don’t really use it anymore.”
U/COSMICRUSH ↗COMMENTS
Add context that might help others — skin type, conditions like PCOS, what you'd tried before. The more specific, the more useful.
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