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Microneedling combined with chemical peels showed the best results for acne scar improvement across 24 RCTs with 1,546 participants.
view on pubmed ↗← BACK TO VEDA
SKINCARE
• MIXED
Polynucleotides for Atrophic Acne Scar Treatment
RESEARCH
- Microneedling and lasers have solid evidence for improving atrophic acne scars, but polynucleotides haven't been specifically studied for this—so there's no real proof they work.
COMMUNITY
- Limited public discussion found — the research above gives a reasonable starting expectation
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SAFETYPolynucleotide injections are generally safe for most people, but those with active skin infections, severe allergies, or on blood thinners should check with a doctor first.
WHAT THE RESEARCH SAYS
ALL 15 ON PUBMED ↗02
All 33 microneedling studies for acne scars showed improvement in scar appearance, though efficacy varied when compared to dual therapies.
view on pubmed ↗03
Lasers (fractional, ablative, non-ablative) and microneedling have the strongest evidence-based support for atrophic acne scars.
view on pubmed ↗04
Adipose-derived stem cell exosomes as adjuvant after fractional CO₂ laser showed clinical benefit in a 12-week double-blind split-face trial of 25 patients.
view on pubmed ↗WHAT PEOPLE SAY
READ THREADS ON REDDIT ↗COMMUNITY SENTIMENT
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COMMENTS
Add context that might help others — skin type, conditions like PCOS, what you'd tried before. The more specific, the more useful.
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